| II. GRANT SUPPORT |
| The Role of Transforming Growth Factor - Beta in the Spinal Cord Response to Acute Spinal Trauma. North American Spine Society, October 1993, $12,500.00 funded. |
| Principal Investigator: | Michael E. Joyce, MD |
| Investigators: | Michael F. O’Brien, MD*, Lawrence G. Lenke, MD, Keith H. Bridwell, MD |
| Retrospective and Prospective Surgical Spinal Database (~4,000 entries). Sofamor Danek, 8/96-8/97, $10,000.00 funded |
| Principal Investigator: | Keith H. Bridwell, MD | ||
| Investigators: | Lawrence G. Lenke, MD, K. Daniel Riew, MD |
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| Selective Nerve Root Corticosteroid Injection. Can its use Obviate the Need for Surgery in Patients with Lumbar Radicular Pain? BJC Health System-Innovations in Healthcare, 12/96-12/98, $19,350.00 funded |
| Principal Investigator: | K. Daniel Riew, MD | ||
| Investigators: | Yuming Yin, MD, Lawrence G. Lenke, MD, Keith H. Bridwell, MD, Lou Gilula, MD | ||
| Structural and Performance Changes in Adolescent Idiopathic Scoliosis Patients Undergoing Anterior vs. Posterior Thoracic Spinal Fusion. DePuy-Motech, Inc., 2/97-2/99, $84,000.00 funded |
| Principal Investigators: | Lawrence G. Lenke, MD, Jack R. Engsberg, PhD | ||
| Coinvestigators: | James Kemp, MD, Marilyn Siegel, MD, Keith H. Bridwell, MD | ||
| Biomechanics of Spinopelvic Fixation in a Human Cadaveric Model of Isthmic Spondylolisthesis. Sofamor Danek, 97-6/99, extended to 6/01, $50,556.00 1st year, $35,000.00 2nd year, funded |
| Principal Investigator: | Keith H. Bridwell, MD | ||
| Coinvestigators: | Stephen J. Lewis, MD*, Ravishankar Vedantam, MD, Douglas Linville, MD*, John Long, DVM, Bryan W. Cunningham, MSc, Lawrence G. Lenke, MD |
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| An Open-Label, Randomized, Parallel-Group Study Comparing the Perioperative Administration of Procrit7 (Epoetin Alfa) to the Standard of Care in Blood Conservation for Idiopathic Pediatric/Adolescent Scoliosis and Adult Spinal Deformity Surgeries. Ortho-Biotech, Inc., 7/98-12/99, $60,000.00 funded |
| Principal Investigator: | Keith H. Bridwell, MD | ||
| Coinvestigators: | Lawrence G. Lenke, MD, Terri G. Monk, MD | ||
| Structural and Performance Changes in AIS Patients Fused into the Mid and Lower Lumbar Spine. Sofamor Danek, 8/98-8/00, $75,000.00 funded |
| Principal Investigators: | Lawrence G. Lenke, MD, Jack R. Engsberg, PhD | ||
| Coinvestigators: | James S. Kemp, MD, Keith H. Bridwell, MD, George S. Bassett, MD | ||
| Outcomes in Adolescents having Scoliosis Fusion Surgery. Sofamor Danek, NIH R-01, 10/98 (not accepted), revised 7/99, $1,275,228.00 |
| Principal Investigators: | Lawrence G. Lenke, MD, Keith H. Bridwell, MD | ||
| Coinvestigators: | Jack R. Engsberg, PhD, George S. Bassett, MD, Sandy A. Ross, MD, James S. Kemp, MD, Kevin W. Hollander, MS, ME, Kyongta Ty Bae, MD, PhD, Kenneth B. Schechtman, MD |
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| Comparison of Outcome Measures in Adult Scoliosis Patients Undergoing an Extended Spinal Fusion to L5 or Sacrum or Revision of Previous Long Spinal Deformity Fusion Surgery. Scoliosis Research Society, 10/98-9/01, Barnes-Jewish Hospital Grant, $80,308.00 funded |
| Principal Investigator: | Keith H. Bridwell, MD | ||
| Coinvestigators: | Scott D. Minor, PhD, Lawrence G. Lenke, MD, Jack R. Engsberg, PhD | ||
| Amicar versus Aprotinin in Controlling Blood Loss in Scoliosis Surgery. Orthopaedic Research and Education Foundation, 7/98-6/00, $42,722.00 funded |
| Principal Investigator: | Lawrence G. Lenke, MD |
| Coinvestigators | George S. Bassett, MD, Jennifer Cole, MD |
| Spinal Patients Outcomes Research Trial (SPORT) - Low Back Pain: A Multi-Center Trial. National Spine Network, 7/99-6/04, 5U01AR4544-02, $79,235.00 funded |
| Principal Investigator: | James N. Weinstein, DO, MS | ||
| Site PI: | Lawrence G. Lenke, MD | ||
| Site Investigators: | Keith H. Bridwell, MD, K. Daniel Riew, MD, Ralph Dacey, MD, Carl Lauryssen, MD | ||
| Genetic Manipulation of the Secondary Injury Cascade of Acute Spinal Cord Injury. Medtronic Sofamor Danek 1/00-12/01 $25,000.00 funded |
| Coinvestigators: | Jueren Lou, PhD, F. Xu, PhD, Lawrence G. Lenke, MD | ||
Mentored Research Scientist Award. 3/00-2/05, no financial support |
| Center of Gravity Investigation in Scoliosis. Max-Biedermann-Institut, Berlin, Germany, 7/00-6/01, $40,440.00 |
| Coinvestigators: | Lawrence G. Lenke, MD, Jack R. Engsberg, PhD, Kyongta Tye Bae, MD, PhD | ||
| Effect of Additional Oxygen on Infection following Spine Fusion Surgery in Patients with Neuromuscular Scoliosis. Shriners Hospital Clinical Outcomes Planning, 1/01-12/01 (not accepted), $50,000.00/year |
| Principal Investigator: | Dean A. Blumberg, MD | ||
| Coinvestigators: | Stephen Skinner, MD, Randal R. Betz, MD, Lawrence G. Lenke, MD, Paul C. Rudoy, MD John Scavone, MD |
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| Prospective Comparison of Postoperative Range of Motion Exercise after Adolescent Idiopathic Scoliosis Fusion. Shriners Hospital COSAB Grant, 8/00 (not accepted) revised 1/02, $70,000.00 |
| Coinvestigators: | Jack R. Engsberg, PhD, Lawrence G. Lenke, MD | ||
| Idiopathic Scoliosis: Gene Mapping and Identification. Scoliosis Research Society, Foundation Yves Cotrel, 10/03-09/05, $49,177.00 funded |
| Principal Investigator: | Matthew B. Dobbs, MD |
| Coinvestigators | Michael Lovett, PhD, Michael Whyte, MD, Lawrence Lenke, MD |
| Prospective Pediatric Scoliosis Study. Medtronic Sofamore Danek, 10/03-09/08, $50,000.00 funded |
| Principal Investigators: | Lawrence Lenke, MD, Matthew B. Dobbs, MD |
| Coinvestigator | Keith Bridwell, MD |
| Spinal Patients Outcomes Research Trial (SPORT) - Multi-Center Study. National Institute of Health (NIH), 5/04-5/05, $503,252.00 locally ($13,546,017.00 nationally) |
| Principal Investigator:: | Lawrence G. Lenke, MD |
| Coinvestigators | Keith H. Bridwell, MD, K. Daniel Riew, MD, Ralph G. Dacey, Jr., MD, Carl Lauryssen, MD, Anthony Margherita, MD, Heidi Prather, DO |
| Bracing in Adolescent Idiopathic Scoliosis (BrAIST). National Institute for Health, 12/04-12/09, $242,260.00 locally (6,500,000.00 nationally) (pending) |
| Principal Investigator I: | Stuart Weinstein, MD | ||
| Site Principal Investigators: | Matthew B. Dobbs, MD | ||
| Site Coinvestigators | Lawrence Lenke, MD, Keith Bridwell, MD | ||
| Washington University Spine Service Clinical Research Grant. Medtronic, Washington University Spine Research Institute, 3/05-2/10, $1,948,615.00 | |||
| Coinvestigators | Lawrence G. Lenke, MD, Keith H. Bridwell, MD, K. Daniel Riew, MD | ||
| * Fellow | ‡ Resident | ¥ Student | § International Fellow |
